|Application ||WB, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||44882 Da|
|Other Names||LAMP-1, Lysosome associated membrane protein 1|
|Format||100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||LAMP-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome|
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Provided below are standard protocols that you may find useful for product applications.
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is tho µght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, s µggesting that each protein possesses some unique and necessary functions.
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