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LAMP-1 Antibody (Center)

Purified Rabbit Polyclonal Antibody

  • WB - LAMP-1 Antibody (Center) ABV11572
    Western blot analysis of LAMP-1 in EL4 cell lysate with LAMP-1 antibody at A(1ug/ml) and B(2ug/ml).
  • IF - LAMP-1 Antibody (Center) ABV11572
    Immunofluorescence of LAMP-1 in human colon tissue with LAMP-1 antibody at 20ug/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11279
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 44882 Da
Additional Information
Gene ID 3916
Other Names LAMP-1, Lysosome associated membrane protein 1
Target/Specificity LAMP-1
Format 100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsLAMP-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMP1
Function Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome
Research Areas
Citations (0)

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Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is tho µght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, s µggesting that each protein possesses some unique and necessary functions.

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$ 325.00
Cat# ABV11572
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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