|Reactivity||Human, Mouse, Rat|
|Calculated MW||47748 Da|
|Other Names||TGF-b2, TGF b2 TGF-beta2, TGF beta-2, TGFbeta, TGFb2, transforming growth factor beta 2|
|Formulation||100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||TGF-beta2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.|
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The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal thro µgh the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.
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