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TRAIL Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P50591 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32509 Da |
| Gene ID | 8743 |
|---|---|
| Other Names | Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL |
| Target/Specificity | TRAIL |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-human TRAIL polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Background Descriptions | |
| Precautions | TRAIL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF10 |
|---|---|
| Synonyms | APO2L, TRAIL |
| Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form. |
| Tissue Location | Widespread; most predominant in spleen, lung and prostate |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2 Ligand (Apo2L), is a cytotoxic protein that activates rapid apoptosis in tumor cells, but not at normal cells. Human TRAIL/Apo2L is a single polypeptide chain containing 168 amino acids and has a molecular mass of 19.6 kDa.
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