|Application ||WB, IHC|
|Calculated MW||46883 Da|
|Other Names||VEGF C, Vascular Endothelial Growth Factor C , Vascular endothelial growth factor-related protein C; VRP|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti- VEGF-C polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||VEGF-C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.|
|Tissue Location||Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte|
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Vascular Endothelial Growth Factor-C (VEGF-C) is a 125 amino acid protein that plays an important role in angiogenesis and many other biological processes. Human VEGF-C exhibits about 85% homology with murine VEGF-C.
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