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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Visfatin Antibody   

Visfatin Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Visfatin Antibody ABV11615
    Western blot analysis using recombinant human Visfatin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43490
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55521 Da
Additional Information
Gene ID 10135
Other Names Nampt, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, PBEF, visceral fat-derived hormone
Target/Specificity Visfatin
Format 100 µg (0.5 mg/ml) affinity purified rabbit anti-Visfatin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsVisfatin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PBEF, PBEF1
Function Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum
Tissue Location Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues
Research Areas
Citations (0)

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Visfatin is a cytokine highly expressed in visceral fat and blood. This protein has also been reported to be a cytokine (PBEF) that promotes B cell maturation and inhibits neutrophil apoptosis. Visfatin is tho µght to have insulin-like activities and is able to bind insulin receptor and thus, may lead to lowering blood glucose levels.

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$ 245.00
$ 89.00
Cat# ABV11615
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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