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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Thioredoxin Reductase 1 (TXNRD1) Antibody   

Thioredoxin Reductase 1 (TXNRD1) Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Thioredoxin Reductase 1 (TXNRD1) Antibody ABV11645
    Western blot with human TXNRD1 antibody. Lane1: 22ug human serum; Lane2: 60ug 3T3 cell lysate; Lane3: 22ug mouse muscle; Lane4: 60ugrat kidney; Lane5: 80ug Rat liver.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16881
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype rabbit IgG
Calculated MW 70906 Da
Additional Information
Gene ID 7296
Other Names Thioredoxin Reductase, GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR
Target/Specificity Thioredoxin Reductase 1 (TXNRD1)
Format 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsThioredoxin Reductase 1 (TXNRD1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GRIM12, KDRF
Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Cellular Location Cytoplasm. Isoform 5: Cytoplasm.
Tissue Location Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver
Research Areas
Citations (0)

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Thioredoxin reductase 1 is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

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$ 265.00
$ 89.00
Cat# ABV11645
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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