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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Phospho-Bcl-2 (Thr56) antibody   

Phospho-Bcl-2 (Thr56) antibody

Purified Rabbit Polyclonal Antibody

  • WB - Phospho-Bcl-2 (Thr56) antibody ABV11671
    Western blot analysis of Jurkat cells using Phospho-Bcl-2(Thr56) Polyclonal antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10415
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26266 Da
Additional Information
Gene ID 596
Other Names BCL2; Apoptosis regulator Bcl-2
Target/Specificity Bcl-2 (Thr56)
Format 100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsPhospho-Bcl-2 (Thr56) antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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The Bcl-2 family of proteins is the best characterized protein family involved in the regulation of apoptotic cell death in variety of cells. Bcl2 is an integral outer mitochondrial membrane protein that regulates mitochondrial calcium homeostasis and proton flux. Several reports suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or S87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes.

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$ 285.00
Cat# ABV11671
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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