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Anti-human Caveolin-1 antibody

Purified Mouse Monoclonal Antibody

     
  • WB - Anti-human Caveolin-1 antibody ABV11685
    Detection of Caveolin-1 Western blotting. 1.MM1(melanoma cell) derived exosome(20ug). 2.MM1 whole lysate(20ug).
  • FC - Anti-human Caveolin-1 antibody ABV11685
    Staining of Caveolin-1 in MM1 purified exosomes.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC
Primary Accession Q03135
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG2b
Calculated MW 20472 Da
Additional Information
Gene ID 857
Other Names Caveolin-1, CAV1, CAV
Target/Specificity Caveolin (unconjugated)
Formulation 0.5 mg/ml in Glycine (0.1 M), NaCl (0.5 M), Tris-HCl (0.1 M) with sodium azide (15mM), pH: 7.4.
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsAnti-human Caveolin-1 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane Membrane protein of caveolae
Tissue Location Expressed in muscle and lung, less so in liver, brain and kidney
Citations (0)

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Background

The lipid raft-associated protein Caveolin-1 (CAV1) is the major component of the inner surface of caveolae, small ivaginations of the plasma membrane. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmatic signaling molecules. It is highly expressed on exosomes derived from tumor tissues.

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$ 365.00
Cat# ABV11685
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