|Application ||WB, FC|
|Calculated MW||20472 Da|
|Other Names||Caveolin-1, CAV1, CAV|
|Formulation||0.5 mg/ml in Glycine (0.1 M), NaCl (0.5 M), Tris-HCl (0.1 M) with sodium azide (15mM), pH: 7.4.|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Anti-human Caveolin-1 antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane Membrane protein of caveolae|
|Tissue Location||Expressed in muscle and lung, less so in liver, brain and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The lipid raft-associated protein Caveolin-1 (CAV1) is the major component of the inner surface of caveolae, small ivaginations of the plasma membrane. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmatic signaling molecules. It is highly expressed on exosomes derived from tumor tissues.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.