|Application ||WB, FC|
|Calculated MW||20472 Da|
|Other Names||Caveolin-1, CAV1, CAV|
|Formulation||0.5 mg/ml in Glycine (0.1 M), NaCl (0.5 M), Tris-HCl (0.1 M) with sodium azide (15mM), pH: 7.4.|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Anti-human Caveolin-1 antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane Membrane protein of caveolae|
|Tissue Location||Expressed in muscle and lung, less so in liver, brain and kidney|
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The lipid raft-associated protein Caveolin-1 (CAV1) is the major component of the inner surface of caveolae, small ivaginations of the plasma membrane. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmatic signaling molecules. It is highly expressed on exosomes derived from tumor tissues.
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