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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD47/MER6 Polyclonal Antibody   

CD47/MER6 Polyclonal Antibody

Rabbit Anti Human Polyclonal Antibody

     
  • FC - CD47/MER6 Polyclonal Antibody ABV11723
    RSC96 cells probed with CD47 polyclonal antibody, Unconjugated at 1:100 for 30 minutes followed by incubation with a PE conjugated secondary(green) for 30 minutes compared to control cells(blue), secondary only(light blue) and isotype control(organge).
  • IHC - CD47/MER6 Polyclonal Antibody ABV11723
    Formalin-fixed and paraffin embedded Rat tongue tissue labeled with anti-CD47 polyclonal antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, FC
Primary Accession Q08722
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35214 Da
Additional Information
Gene ID 961
Positive Control IHC, FC
Application & Usage IHC-P~~1:100~1:500 FC~~1:20~1:100
Other Names IAP; OA3; MER6; Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein; Protein MER6; CD47
Target/Specificity CD47
Antibody Form Liquid
Appearance Colorless liquid
Formulation 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCD47/MER6 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD47
Synonyms MER6
Function Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain
Research Areas
Citations (0)

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Background

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

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$ 275.00
Cat# ABV11723
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