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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ICOS / CD278 Antibody   

ICOS / CD278 Antibody

Rabbit Anti Human Polyclonal Antibody

     
  • FC - ICOS / CD278 Antibody ABV11727
    FC analysis of Jurkat cells.
  • IHC - ICOS / CD278 Antibody ABV11727
  • WB - ICOS / CD278 Antibody ABV11727
    Western blot analysis of CD27 antibody in Jurkat cell lysates.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC
Primary Accession Q9Y6W8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22625 Da
Additional Information
Gene ID 29851
Positive Control WB: Jurkat cell lysate, FC: Jurkat cells, IHC: human lymph
Application & Usage WB; 1:1000, IHC-P; 1:50~100, FC; 1:10~51
Other Names Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Target/Specificity ICOS
Antibody Form Liquid
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide. 
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsICOS / CD278 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICOS
Synonyms AILIM
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Research Areas
Citations (0)

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Background

ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

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$ 155.00
Cat# ABV11727
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