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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AKR1C3 Polyclonal Antibody   

AKR1C3 Polyclonal Antibody

Rabbit Polyclonal Antibody

     
  • WB - AKR1C3 Polyclonal Antibody ABV11765-100
    Western blot analysis of h AKR1C3 using anti-h AKR1C3 antibody: Lane1(Hela cell lysate); Lane2(h AKR1C3,10ng); Lane3(h AKR1C3,50ng)
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, DB
Primary Accession P42330
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 36853 Da
Additional Information
Gene ID 8644
Positive Control Western blot
Application & Usage Western blot: 1-4 µg/ml, Dot blot: 1-4 µg/ml
Alias Symbol AKR1C3
Other Names Aldo-keto reductase family 1, member C3, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5
Appearance Colourless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAKR1C3 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1C3
Synonyms DDH1, HSD17B5, KIAA0119, PGFS
Function Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Cellular Location Cytoplasm.
Tissue Location Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Research Areas
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Background

Aldo-keto reductase family 1 member C3 in humans is encoded by the AKR1C3 gene. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.

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$ 265.00
$ 89.00
Cat# ABV11765-100
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