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SMO Antibody (Center)

Rabbit Polyclonal Antibody

     
  • WB - SMO Antibody (Center) ABV11768-100
    Western blot analysis in HepG2 cell line Lysates using SMO purified antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q99835
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 86397 Da
Additional Information
Gene ID 6608
Positive Control Western blot
Application & Usage WB: 1:1000
Alias Symbol SMO
Other Names SMO Antibody (Center) polyclonal antibody, SMO antibody, Smoothened homolog antibody, SMO antibody, SMO polyclonal antibody, SMOH antibody
Appearance Colourless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS with 0.09% (W/V) sodium azide.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSMO Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMO
Synonyms SMOH
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.

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$ 265.00
Cat# ABV11768-100
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