|Calculated MW||86397 Da|
|Positive Control||Western blot|
|Application & Usage||WB: 1:1000|
|Other Names||SMO Antibody (Center) polyclonal antibody, SMO antibody, Smoothened homolog antibody, SMO antibody, SMO polyclonal antibody, SMOH antibody|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS with 0.09% (W/V) sodium azide.|
|Reconstitution & Storage||-20 °C|
|Precautions||SMO Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell projection, cilium|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
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