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5-Hydroxytryptamine Receptor 1A Antibody

Rabbit Polyclonal Antibody

     
  • WB - 5-Hydroxytryptamine Receptor 1A Antibody</p> ABV11769-100
    Western blot analysis of mouse brain membrane (lanes1 and 3) and rat brain membrane (lanes2 and 4). Anti-5-Hydroxytryptamine Receptor 1A antibody (1:200).
  • IHC - 5-Hydroxytryptamine Receptor 1A Antibody</p> ABV11769-100
    Expression of 5-HT1A in rat cerebellum. Immunohistochemical staining of rat cerebellum frozen section using Anti-5-Hydroxytryptamine Recepteor 1A antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P19327
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46429 Da
Additional Information
Gene ID 24473
Positive Control Western blot, IHC
Application & Usage WB: 1:200-1:2000, IHC: 1:100
Other Names 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A, Htr1a, 5ht1a
Appearance Colourless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS, pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution & Storage -20 °C
Background Descriptions
Precautions5-Hydroxytryptamine Receptor 1A Antibody

is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Htr1a
Synonyms 5ht1a
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus
Research Areas
Citations (0)

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Background

Serotonin [5-hydroxytryptamine (5-HT1)] is an important neurotransmitter in the CNS that exerts its neuronal activity via 5-HT receptors. 5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-Protein Coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels. The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1e AND 5-HT1F) which share 41-63% overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species. Activation of 5-HT1A receptor decreases blood pressure and heart rate, involved in learning, memory, relieving anxiety and depression. 5-Hydroxytryptamine Receptor

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$ 305.00
Cat# ABV11769-100
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