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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-CD40L (Ruplizumab), Human IgG1 Antibody   

Anti-CD40L (Ruplizumab), Human IgG1 Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession P29965
Reactivity Human
Host Recombinant
Clonality Monoclonal
Isotype Human IgG1, kappa
Calculated MW 29274 Da
Additional Information
Gene ID 959
Alias Symbol CD40LG
Other Names CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-CD40L (Ruplizumab), Human IgG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD40LG
Synonyms CD40L, TNFSF5, TRAP
Function Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T- cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).
Cellular Location Cell membrane; Single-pass type II membrane protein Cell surface
Tissue Location Specifically expressed on activated CD4+ T- lymphocytes
Research Areas
Citations (0)

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Background

Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531  ± 155 hours.

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$ 595.00
Cat# ABV11788-200
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