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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cystathionine β-Synthase Antibody   

Cystathionine β-Synthase Antibody

Rabbit Polyclonal Antibody

     
  • WB - Cystathionine β-Synthase Antibody ABV11806-100
    Western blot analysis of CBS using anti-CBS antibody: Lane1-3(2ng, 10ng, 50ng); Lane4(Hela cell lysate)
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P35520
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 60587 Da
Additional Information
Gene ID 102724560;875
Positive Control WB: Hela cell lysates, rh-CBS
Application & Usage WB: 1-4 µg
Alias Symbol CBS
Other Names Beta-thionase, Serine sulfhydrase, Cystathionine beta-synthase
Appearance Colorless liquid
Formulation In PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCystathionine β-Synthase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBS
Function Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L- homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
Cellular Location Cytoplasm. Nucleus
Tissue Location In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney
Research Areas
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Background

Cystathionine β-synthase (CBS; E.C. 4.2.1.22) is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism in eukaryotes. CBS catalyzes condensation between serine and homocysteine to generate cystathionine, which is then further processed by cystathionine γ-lyase to yield cysteine. The gene encoding CBS is essentially linked to the genetic disorders of homocystinuria and Down syndrome. Homocystinuria is an autosomal recessive disease, characterized by high plasma levels of homocysteine, with clinical manifestations including mental retardation, thromboembolism and connective tissue defects. In addition, CBS also mediates synthesis of hydrogen sulfide by catalyzing condensation between cysteine and homocysteine. CBS is highly expressed in the nervous system, liver and kidney and is responsible for up to 95% of the H2S production in the brain.

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$ 265.00
$ 89.00
Cat# ABV11806-100
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