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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-KI67 Rabbit Monoclonal Antibody   

Anti-KI67 Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibody

     
  • IHC - Anti-KI67 Rabbit Monoclonal Antibody ABV11829-100
    Immunohistochemical staining of FFPE human breast cancer tissue sections, using anti-Human KI67 Rabbit Monoclonal antibody.
  • IHC - Anti-KI67 Rabbit Monoclonal Antibody ABV11829-100
    Immunohistochemical staining of FFPE human tonsil tissue sections, using anti-human KI67 rabbit monoclonal antibody.
  • WB - Anti-KI67 Rabbit Monoclonal Antibody ABV11829-100
    Western blot of Hela and K562 cell lysates using anti-KI67 rabbit monoclonal antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P46013
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Isotype Rabbit IgG
Calculated MW 358694 Da
Additional Information
Gene ID 4288
Positive Control WB: HeLa and K562 cell lysate; IHC: human breast cancer and tonsil tissue
Application & Usage IHC: 1:100 - 1:400 dilution ; WB: 1:100 - 1:500 dilution
Alias Symbol MKI67
Other Names KIA, KI-67, MKI67
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-KI67 Rabbit Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKI67 (HGNC:7107)
Function Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Cellular Location Chromosome. Nucleus. Nucleus, nucleolus Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106)
Research Areas
Citations (0)

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Background

Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.

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$ 125.00
Cat# ABV11829-100
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