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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RhoGDI Antibody   

RhoGDI Antibody

Rabbit Polyclonal Antibody

     
  • IHC - RhoGDI Antibody ABV11855-100
    Immunohistochemical analysis of RhoGDI alpha staining in human breast cancer formalin fixed paraffin embedded tissue section.
  • WB - RhoGDI Antibody ABV11855-100
    Western blot analysis of RhoGDI alpha experssion in A549(A); DLD(B); HepG2© whole cell lysates.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P52565
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 23207 Da
Additional Information
Gene ID 396
Positive Control WB:A549, DLD, HepG2 cell lysates; IHC: human breast cancer tissue
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
Alias Symbol ARHGDIA
Other Names GDIA1, Rho GDP-dissociation inhibitor 1, Rho GDI 1, Rho-GDI
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsRhoGDI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGDIA
Synonyms GDIA1
Function Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.

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$ 295.00
Cat# ABV11855-100
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