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Anti- ALPK1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q96QP1 |
| Reactivity | Human |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Calculated MW | 138861 Da |
| Gene ID | 80216 |
|---|---|
| Positive Control | WB: LO2, HCT116, COLO205, HepG2 lysate; IHC: human breast cancer tissue; IF: HepG2 cells |
| Application & Usage | WB; 1:500 – 1:2000, IH; 1:100 – 1:200, IF/IC; 1:100 – 1:500 |
| Other Names | KIAA1527; LAK; Alpha-protein kinase 1; Chromosome 4 kinase; Lymphocyte alpha-protein kinase |
| Target/Specificity | ALPK1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Handling | The antibody solution should be gently mixed before use |
| Reconstitution & Storage | -20°C |
| Background Descriptions | |
| Precautions | Anti- ALPK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALPK1 {ECO:0000303|PubMed:30111836, ECO:0000312|HGNC:HGNC:20917} |
|---|---|
| Function | Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta- D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram- negative and some Gram-positive bacteria (PubMed:30111836). ADP- Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). May play a role in ciliogenesis (PubMed:30967659). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localized at the base of primary cilia. |
| Tissue Location | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659) |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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