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Anti-CNOT7 Antibody

     
  • WB - Anti-CNOT7 Antibody  ABV11966-100
    WB analysis of CNOT7 expression in HeLa (A); HuvEc (B); DKD (C); mouse brain (D); rat brain (E) whole cell lysates
  • IHC - Anti-CNOT7 Antibody  ABV11966-100
    Immunohistochemical analysis of CNOT7 staining In human ovarian cancer formalin fixed paraffin embedded tissue section.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IH
Primary Accession Q9UIV1
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype Rabbit IgG
Calculated MW 32745 Da
Additional Information
Gene ID 29883
Positive Control WB: HeLa, HuvEc, DKD, mouse brain, rat brain lysates ; IHC: human ovarian cancer tissue
Application & Usage WB; 1:500 – 1:2000, IH; 1:50 – 1:200
Other Names CAF1, CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a
Target/Specificity CNOT7
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsAnti-CNOT7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNOT7
Synonyms CAF1
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity.
Cellular Location Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.
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$ 295.00
Cat# ABV11966-100
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