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Anti-ATIC Antibody (3H12-C9-H9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P31939 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 3H12-C9-H9 |
| Calculated MW | 64616 Da |
| Gene ID | 471 |
|---|---|
| Application & Usage | WB: A549, A431, LNCaP, Jurkat, U20S, HeLa cell lysate, Rat liver tissue lysate, Mouse kidney tissue lysate, Mouse brain, Mouse colon tissue lysate |
| Other Names | Bifunctional purine biosynthesis protein PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase, IMP cyclohydrolase, IMP synthase, Inosinicase |
| Target/Specificity | Bifunctional purine biosynthesis protein PURH |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-ATIC Antibody (3H12-C9-H9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATIC (HGNC:794) |
|---|---|
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6- mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113} |
| Tissue Location | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
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