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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Functional Antibodies   >   Functional NS5B (HCV) Antibody, mAb (blocking)   

Functional NS5B (HCV) Antibody, mAb (blocking)

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Host Purified From Concentrated Hybridoma Tissue Culture Supernatant.
Clonality Monoclonal
Isotype Mouse IgG2a
Gene Source HCV
Application Note ICC(1:100),IP,Functional Application, Blocks the RNA-dependent RNA polymerase activity in vitro,Note, Not suitable for WB.
Clone Names 5B-12B7
Additional Information
Other Names Nonstructural Protein 5B
Target/Specificity Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
Format Liquid. In PBS containing 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional NS5B (HCV) Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
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The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.

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$ 330.00
Cat# ADP0014
(40 western blots)
Availability: 3-5 days
Bulk Size
Seasonal Special on Bulk Order
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