|Application ||ICC, IP|
|Host||Purified From Concentrated Hybridoma Tissue Culture Supernatant.|
|Application Note||ICC(1:100),IP,Functional Application, Blocks the RNA-dependent RNA polymerase activity in vitro,Note, Not suitable for WB.|
|Other Names||Nonstructural Protein 5B|
|Target/Specificity||Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.|
|Format||Liquid. In PBS containing 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional NS5B (HCV) Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
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