|Application ||WB, IHC, ICC, E, IP|
|Host||Purified From Concentrated Hybridoma Tissue Culture Supernatant.|
|Endotoxin||<0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza).|
|Application Note||E,Functional Application,Inhibition,ICC,IHC,IP(10 µg/ml),WB(5 µg/ml)|
|Calculated MW||57449 Da|
|Other Names||Lymphocyte Activation Gene-3; FDC Protein; CD223|
|Target/Specificity||Recognizes human and monkey LAG-3.|
|Format||Liquid. In PBS containing 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional LAG-3 Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in lymphocyte activation. Binds to HLA class-II antigens.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||On cell surface of activated NK and T- lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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