|Application ||WB, IHC-F, ICC, IP|
|Endotoxin||<0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza).|
|Application Note||Functional Application,Inhibition,ICC,IHC-F (1:150),IP(10 µg/ml),WB(5 µg/ml)|
|Other Names||Lymphocyte Activation Gene-3; FDC Protein; CD223|
|Target/Specificity||Recognizes human LAG-3.|
|Format||Liquid. In PBS containing 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional LAG-3 (human) Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for replication. EMBL; X17655; CAA35647.1; -; Genomic_DNA. EMBL; X72021; CAA50899.1; -; Genomic_DNA. PIR; I39478; I39478. RefSeq; NP_044463.1; NC_001797.1. RefSeq; NP_053002.1; NC_002136.1. RefSeq; WP_010890218.1; NC_002136.1. GeneID; 1113363; -. GeneID; 1113371; -. GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. InterPro; IPR014820; PriCT_1. Pfam; PF08708; PriCT_1; 1. 4: Predicted; DNA replication; DNA-binding; Plasmid. CHAIN 1 496 Protein RepR. /FTId=PRO_0000068335. DNA_BIND 120 141 SEQUENCE 496 AA; 57409 MW; 43DFB9B721CA2098 CRC64; MNIPFVVETV LHDGLLKYKF KNSKIRSITT KPGKSKGAIF AYRSKKSMIG GRGVVLTSEE AIHENQDTFT HWTPNVYRYG TYADENRSYT KGHSENNLRQ INTFFIDFDI HTEKETISAS DILTTAIDLG FMPTLIIKSD KGYQAYFVLE TPVYVTSKSE FKSVKAAKII SQNIREYFGK SLPVDLTCNH FGIARIPRTD NVEFFDPNYR YSFKEWQDWS FKQTDNKGFT RSSLTVLSGT EGKKQVDEPW FNLLLHETKF SGEKGLVGRN SVMFTLSLAY FSSGYSIETC EYNMFEFNNR LDQPLEEKEV IKIVRSAYSE NYQGANREYI TILCKAWVSS DLTSKDLFVR QGWFKFKKKR SERQRVHLSE WKEDLMAYIS EKSDVYKPYL ATTKKEIREV LGIPERTLDK LLKVLKANQE IFFKIKPGRN GGIQLASVKS LLLSIIKLKK EERESYIKAL TASFNLERTF IQETLNKLAE RPKTDPQLDL FSYDTG|
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Provided below are standard protocols that you may find useful for product applications.
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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