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>   home   >   Products   >   Primary Antibodies   >   EIF4E Antibody (S1232)   

EIF4E Antibody (S1232)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EIF4E  Antibody (S1232) AE1011c
    Western blot analysis of extracts from 293 cell using EIF4E Antibody (S1232) (#AE1011c, Lane 1 and 2) and Phospho-EIF4G-S-1232 Antibody (#AE1011d, Lane 3 and 4).
  • IHC - EIF4E  Antibody (S1232) AE1011c
    Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using EIF4E Antibody (S1232) (#AE1011c).
  • IF - EIF4E  Antibody (S1232) AE1011c
    Immunofluorescence staining of methanol-fixed HeLa cells using EIF4E Antibody (S1232)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04637
Reactivity Human
Host Rabbit
Clonality Polyclonal
Concentration 1mg/ml
Isotype Rabbit IgG
Calculated MW 175491 Da
Additional Information
Gene ID 1981
Other Names Eukaryotic translation initiation factor 4 gamma 1, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220, EIF4G1, EIF4F, EIF4G, EIF4GI
Target/Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution WB~~1:500~1:1000
Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEIF4E Antibody (S1232) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF4G1
Synonyms EIF4F, EIF4G, EIF4GI
Function Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Citations (0)

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The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.


Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. Tu L, et al. Mol Cancer, 2010 Apr 16. PMID 20398343.
Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. Sukarieh R, et al. J Gen Virol, 2010 May. PMID 20053821.
NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome. Alard A, et al. Mol Cell Biol, 2010 Feb. PMID 20028737.
HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castell贸 A, et al. PLoS One, 2009 Nov 24. PMID 19956697.
The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, et al. J Biol Chem, 2009 Dec 18. PMID 19850929.

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$ 325.00
Cat# AE1011c
(40 western blots)
Availability: 7-10 days
Bulk Size
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