|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||55364 Da|
|Other Names||Histone deacetylase 2, HD2, HDAC2|
|Target/Specificity||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.|
|Format||affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HDAC2 Antibody (S394) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Widely expressed; lower levels in brain and lung|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. Yang Z, et al. Clin Chem Lab Med, 2010 Aug 24. PMID 20731616.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis. Janssen C, et al. J Neuropathol Exp Neurol, 2010 Jun. PMID 20467334.
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically. Xu X, et al. J Biol Chem, 2010 Jun 11. PMID 20421305.
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Adams H, et al. Expert Opin Ther Targets, 2010 Jun. PMID 20415600.
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