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Her3 (ErbB3) Antibody (Y1328)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Her3 (ErbB3) Antibody (Y1328) AE1015a
    Western blot analysis of extracts from HUVEC cell usingHer3 (ErbB3) Antibody (Y1328) (#AE1015a, Lane 1 and 2) andPhospho-Her3 (ErbB3)-Y1328 Antibody (#AE1015b, Lane 3and 4).
  • IHC - Her3 (ErbB3) Antibody (Y1328) AE1015a
    Immunohistochemical analysis of paraffin-embeddedhuman breast carcinoma tissue using Her3 (ErbB3) Antibody (Y1328) (#AE1015a).
  • IF - Her3 (ErbB3) Antibody (Y1328) AE1015a
    Immunofluorescence staining of methanol-fixed HeLa cells using Her3 (ErbB3) Antibody (Y1328) (#AE1015a, Red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21860
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Concentration 1mg/ml
Isotype Rabbit IgG
Calculated MW 148098 Da
Additional Information
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Target/Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution WB~~1:500~1:1000
Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHer3 (ErbB3) Antibody (Y1328) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
Citations (0)

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.


Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Hinks A, et al. Ann Rheum Dis, 2010 Jul 20. PMID 20647273. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells. Chen L, et al. Cancer Res, 2010 Jul 15. PMID 20587519. [Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes] Nikitin AG, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586186.

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$ 325.00
Cat# AE1015a
(40 western blots)
Availability: 7-10 days
Bulk Size
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