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Integrin Beta-3 Antibody (Y773)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AE1017a | 0.1 mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Integrin Beta-3 Antibody (Y773) - Product info | |
| Application | WB, IHC
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| Primary Accession | P05106 |
| Reactivity | Human, Mouse |
| Concentration | 1mg/ml |
| Isotype | Rabbit IgG |
| Calculated MW | 87058 Da |
Integrin Beta-3 Antibody (Y773) - Additional info | |
| Gene ID 3690 | |
| Other Names CD_antigen=CD61; Flags: Precursor; Platelet membrane glycoprotein IIIa, GPIIIa; Integrin beta-3 | |
| Target/Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | |
| Dilution IHC~~1:50-1:100 | |
| Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Integrin Beta-3 Antibody (Y773) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Integrin Beta-3 Antibody (Y773) - Protein Information | |
| Name ITGB3 | |
| Synonyms GP3A | |
| Function Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis | |
Integrin Beta-3 Antibody (Y773) - Application data
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Western blot analysis of extracts from HUVEC cells using Integrin Beta-3 Antibody (Y773) .
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin Beta-3 Antibody (Y773) (#AE1017a).
Integrin Beta-3 Antibody (Y773) - Related products
AP8672b: ITGB3 Antibody (C-term)
RI12789: ITGB3 predesign siRNA
BP8672b: ITGB3 Antibody (C-term) Blocking Peptide
AJ1408d: Integrin beta-3 (CD61) Antibody
AJ1408e: Integrin beta-3A/CD61 Antibody
AE1017a: Integrin Beta-3 Antibody (Y773)
AE1017b: Integrin Beta-3 Antibody (Y785)
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BACKGROUND
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
REFERENCES
Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease. Addad F, et al. Blood Coagul Fibrinolysis, 2010 Aug 25. PMID 20739877. Platelet gene polymorphisms and risk of bleeding in patients undergoing elective coronary angiography: A genetic substudy of the PRAGUE-8 trial. Motovska Z, et al. Atherosclerosis, 2010 Jul 16. PMID 20691446. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868. The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors. Nie YM, et al. Transfus Med, 2010 Jul 28. PMID 20667040. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
