|Application ||WB, E|
|Other Accession||NP_001032900, 3028|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||26923 Da|
|Other Names||3-hydroxyacyl-CoA dehydrogenase type-2, 220.127.116.11, 17-beta-hydroxysteroid dehydrogenase 10, 17-beta-HSD 10, 18.104.22.168, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 22.214.171.124, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, HSD17B10, ERAB, HADH2, MRPP2, SCHAD, XH98G2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ABAD / HADH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G|
|Function||Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).|
|Tissue Location||Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival. Rauschenberger K, et al. EMBO Mol Med, 2010 Feb. PMID 20077426.
Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. Kristofikov谩 Z, et al. Mol Biosyst, 2009 Oct. PMID 19756307.
Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions? Ozeki T, et al. Int J Urol, 2009 Oct. PMID 19735314.
Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism. Yang SY, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706438.
ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease. Marques AT, et al. Mini Rev Med Chem, 2009 Jul. PMID 19601895.
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