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ABAD / HADH2 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1005a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ABAD / HADH2 Antibody - Product info | |
| Application | WB
|
| Other Accession | NP_001032900 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
ABAD / HADH2 Antibody - Additional info | |
| Other Names HSD17B10; HADH2; ABAD; ERAB; MHBD; 17b-HSD10; hydroxyacyl-Coenzyme A dehydrogenase, type II; type 10 17b-HSD; AB-binding alcohol dehydrogenase; type 10 17beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 10; RP3-339A18.2; 17b-HSD10; CAMR; DUPXp11.22; HCD2; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1; 17-beta-hydroxysteroid dehydrogenase type 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; amyloid-beta binding polypeptide; amyloid-beta peptide binding alcohol dehydrogenase; mental retardation, X-linked, syndromic 10; mental retardation, X-linked, syndromic 11; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain dehydrogenase/reductase family 5C, member 1; short chain type dehydrogenase/reductase XH98G2 | |
| Dilution WB~~1:300~2000 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABAD / HADH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABAD / HADH2 Antibody - Application data
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AF1005a staining (0.3 µg/ml) of Human Brain lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
ABAD / HADH2 Antibody - Related products
AP6307a: ABAD Antibody (Center)
AP6307b: ABAD Antibody (C-term)
AP6307c: HADH2 Antibody (C-term P222)
AP6307d: HADH2 Antibody (Center)
RI12577: HSD17B10 predesign siRNA
LY10129a: HADH2 Over-expression Lysate
BP6307a: ABAD Antibody (Center) Blocking Peptide
BP6307b: ABAD Antibody (C-term) Blocking Peptide
BP6307c: HADH2 Antibody (C-term P222) Blocking Peptide
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BACKGROUND
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
REFERENCES
A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival. Rauschenberger K, et al. EMBO Mol Med, 2010 Feb. PMID 20077426. Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. Kristofikov谩 Z, et al. Mol Biosyst, 2009 Oct. PMID 19756307. Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions? Ozeki T, et al. Int J Urol, 2009 Oct. PMID 19735314. Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism. Yang SY, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706438. ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease. Marques AT, et al. Mini Rev Med Chem, 2009 Jul. PMID 19601895.
