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Goat Anti-ABCB9 / TAPL Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-ABCB9 / TAPL Antibody AF1008a
    AF1008a (3.8 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NP78
Other Accession NP_982269, 23457
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 84475 Da
Additional Information
Gene ID 23457
Other Names ATP-binding cassette sub-family B member 9, ATP-binding cassette transporter 9, ABC transporter 9 protein, hABCB9, TAP-like protein, TAPL, ABCB9, KIAA1520
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ABCB9 / TAPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB9
Synonyms KIAA1520
Function ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Cellular Location Lysosome membrane; Multi- pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514} Note=May be located in membrane rafts
Tissue Location Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages
Research Areas
Citations (0)

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.


Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain. Demirel O, et al. Traffic, 2010 Mar. PMID 20377823.
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.
Functional dissection of transmembrane domains of human TAP-like (ABCB9). Kamakura A, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18952056.
Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL). Zhao C, et al. J Biol Chem, 2008 Jun 20. PMID 18434309.
Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells. Ohara T, et al. Biol Pharm Bull, 2008 Jan. PMID 18175933.

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$ 325.00
Cat# AF1008a
(40 western blots)
Availability: 7-10 days
Bulk Size
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