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ACSL5 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1020a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACSL5 Antibody - Product info | |
| Other Accession | NP_976314 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
ACSL5 Antibody - Additional info | |
| Other Names ACSL5; acyl-CoA synthetase long-chain family member 5; HGNC:16526; ACS2; ACS5; FACL5; fatty-acid-Coenzyme A ligase, long-chain 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACSL5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACSL5 Antibody - Application data
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AF1020a (1 µg/ml) staining of human spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
ACSL5 Antibody - Related products
AP2536a: ACSL5 (FACL5) Antibody (N-term)
RI10080: ACSL5 predesign siRNA
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss. Teng AC, et al. FASEB J, 2009 Jun. PMID 19218499. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. Mashima T, et al. Oncogene, 2009 Jan 8. PMID 18806831. Expression of acyl-CoA synthetase 5 in human epidermis. Gaisa NT, et al. Histol Histopathol, 2008 Apr. PMID 18228202. Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. Zhou Y, et al. Arterioscler Thromb Vasc Biol, 2007 Oct. PMID 17761945.
