|Application ||WB, E|
|Other Accession||NP_060708, 55750, 69923 (mouse)|
|Calculated MW||47137 Da|
|Other Names||Acylglycerol kinase, mitochondrial, hAGK, 184.108.40.206, 220.127.116.11, Multiple substrate lipid kinase, HsMuLK, MuLK, Multi-substrate lipid kinase, AGK, MULK|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Acylglycerol kinase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.|
|Cellular Location||Mitochondrion membrane|
|Tissue Location||Highly expressed in muscle, heart, kidney and brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression. Nouh MA, et al. Cancer Sci, 2009 Sep. PMID 19549252.
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. Epand RM, et al. Biochemistry, 2007 Dec 11. PMID 18004883.
Functions of the multifaceted family of sphingosine kinases and some close relatives. Spiegel S, et al. J Biol Chem, 2007 Jan 26. PMID 17135245.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. Van Overloop H, et al. J Lipid Res, 2006 Feb. PMID 16269826.
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