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Goat Anti-ADRB1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ADRB1 Antibody AF1032a
    AF1032a (0.5 µg/ml) staining of human heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08588
Other Accession NP_000675, 153
Reactivity Human, Mouse, Rat
Predicted Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 51323 Da
Additional Information
Gene ID 153
Other Names Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1, ADRB1R, B1AR
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ADRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRB1
Synonyms ADRB1R, B1AR
Function Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Cellular Location Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
Research Areas
Citations (0)

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The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.


Functional effects of beta(1)-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without beta-blocker administration. Kindermann M, et al. Clin Res Cardiol, 2010 Sep 6. PMID 20821015.
The Arg16Gly-尾(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure. Leineweber K, et al. Naunyn Schmiedebergs Arch Pharmacol, 2010 Oct. PMID 20803192.
Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction. Hakalahti AE, et al. Cardiovasc Diabetol, 2010 Aug 23. PMID 20731869.
Association between Genetic Polymorphisms of Adrenergic Receptor and Diurnal Intraocular Pressure in Japanese Normal-Tension Glaucoma. Gao Y, et al. Ophthalmology, 2010 Aug 10. PMID 20705341.
Polymorphic variants of beta1 adrenergic receptor gene (Ser49Gly & Arg389Gly) in healthy Tamilian volunteers. Ramu P, et al. Indian J Med Res, 2010 Jul. PMID 20693591.

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$ 325.00
Cat# AF1032a
(40 western blots)
Availability: 7-10 days
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