|Application ||WB, E|
|Other Accession||NP_000675, 153|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||51323 Da|
|Other Names||Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1, ADRB1R, B1AR|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ADRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.|
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Provided below are standard protocols that you may find useful for product applications.
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.
Functional effects of beta(1)-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without beta-blocker administration. Kindermann M, et al. Clin Res Cardiol, 2010 Sep 6. PMID 20821015.
The Arg16Gly-尾(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure. Leineweber K, et al. Naunyn Schmiedebergs Arch Pharmacol, 2010 Oct. PMID 20803192.
Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction. Hakalahti AE, et al. Cardiovasc Diabetol, 2010 Aug 23. PMID 20731869.
Association between Genetic Polymorphisms of Adrenergic Receptor and Diurnal Intraocular Pressure in Japanese Normal-Tension Glaucoma. Gao Y, et al. Ophthalmology, 2010 Aug 10. PMID 20705341.
Polymorphic variants of beta1 adrenergic receptor gene (Ser49Gly & Arg389Gly) in healthy Tamilian volunteers. Ramu P, et al. Indian J Med Res, 2010 Jul. PMID 20693591.
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