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ALDH1A1 (Internal) AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1051b | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ALDH1A1 (Internal) Antibody - Product info | |
| Other Accession | NP_000680 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
ALDH1A1 (Internal) Antibody - Additional info | |
| Other Names ALDH1A1; aldehyde dehydrogenase 1 family, member A1 ; ALDC; ALDH-E1; ALDH1; ALDH11; MGC2318; PUMB1; RALDH1; ALDH class 1; acetaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase, liver cytosolic; retinal dehydrogenase 1 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ALDH1A1 (Internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ALDH1A1 (Internal) Antibody - Application data
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AF1051b (1 µg/ml) staining of Human Liver Lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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HEK293 overexpressing ALDH1A1 and probed with AF1051b (mock transfection in first lane).
ALDH1A1 (Internal) Antibody - Related products
AM1846a: ALDH1A1 Antibody (Ascites)
AP1445a: ALDH1A1 Antibody (N-term)
AP1465c: ALDH1A1 Antibody (Center)
RI10225: ALDH1A1 predesign siRNA
LY12320a: AL1A1 Over-expression Lysate
BP1445a: ALDH1A1 Antibody (N-term) Blocking Peptide
BP1465c: ALDH1A1 Antibody (Center) Blocking Peptide
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BACKGROUND
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes.
REFERENCES
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Lugli A, et al. Br J Cancer, 2010 Jul 27. PMID 20606680. High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer. van den Hoogen C, et al. Cancer Res, 2010 Jun 15. PMID 20516116. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Su Y, et al. Cancer Epidemiol Biomarkers Prev, 2010 Feb. PMID 20142235.
