|Application ||WB, IHC, E|
|Other Accession||NP_061041.2, AAF71042.1, 55437|
|Calculated MW||47026 Da|
|Other Names||STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, Pseudokinase ALS2CR2, STRADB, ALS2CR2, ILPIP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ALS2CR2 / ILPIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Highly expressed in heart, skeletal muscle, testis, liver and colon.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
Emerging roles of pseudokinases. Boudeau J, et al. Trends Cell Biol, 2006 Sep. PMID 16879967.
LKB1-dependent signaling pathways. Alessi DR, et al. Annu Rev Biochem, 2006. PMID 16756488.
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Kahn BB, et al. Cell Metab, 2005 Jan. PMID 16054041.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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