|Application ||WB, E|
|Other Accession||NP_000691, 301, 16952 (mouse), 25380 (rat)|
|Predicted||Mouse, Pig, Dog, Cow|
|Calculated MW||38714 Da|
|Other Names||Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANXA1, ANX1, LPC1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Annexin I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.|
|Cellular Location||Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Annexin A1 expression and its prognostic significance in human breast cancer. Wang LP, et al. Neoplasma, 2010. PMID 20353277.
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. de Graauw M, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308542.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage. Nair S, et al. Cancer Lett, 2010 Aug 1. PMID 20163912.
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