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APBB1 / FE65 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1070a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
APBB1 / FE65 Antibody - Product info | |
| Other Accession | NP_663722 |
| Reactivity | Human, Mouse |
| Concentration | 100ug/200ul |
| Isotype | IgG |
APBB1 / FE65 Antibody - Additional info | |
| Other Names APBB1; FE65; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); MGC:9072; RIR ; adaptor protein FE65a2; amyloid beta A4 precursor protein-binding, family B, member 1; stat-like protein | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions APBB1 / FE65 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
APBB1 / FE65 Antibody - Application data
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AF1070a (0.1 µg/ml) staining of NIH/3T3 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
APBB1 / FE65 Antibody - Related products
AP3023a: Phospho-APBB1-S175 Antibody
AP3024a: Phospho-APBB1-S347 Antibody
AP6119a: FE65 (APBB1) Antibody (Center)
RI10322: APBB1 predesign siRNA
BP3023a: Phospho-APBB1-S175 Antibody Blocking Peptide
BP3024a: Phospho-APBB1-S347 Antibody Blocking Peptide
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BACKGROUND
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics. Ward MW, et al. J Neurochem, 2010 Apr. PMID 20405578. Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. Yu HT, et al. J Cell Biochem, 2010 Mar 1. PMID 20091743. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121. Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65. Lee EJ, et al. Exp Mol Med, 2009 Aug 31. PMID 19381069.
