|Application ||WB, E|
|Other Accession||NP_001658, 402|
|Calculated MW||20878 Da|
|Other Names||ADP-ribosylation factor-like protein 2, ARL2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ARL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.|
|Cellular Location||Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle Not detected to interphase microtubules.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes.
Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. Zhang T, et al. Structure, 2009 Apr 15. PMID 19368893.
Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line. B茅ghin A, et al. Cell Cycle, 2008 Oct. PMID 18818514.
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. Veltel S, et al. FEBS Lett, 2008 Jul 23. PMID 18588884.
Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure. Shultz T, et al. FASEB J, 2008 Jan. PMID 17704193.
ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells. Beghin A, et al. Exp Cell Res, 2007 Feb 1. PMID 17188265.
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