|Application ||WB, E|
|Other Accession||NP_000342, 412|
|Calculated MW||65492 Da|
|Other Names||Steryl-sulfatase, 220.127.116.11, Arylsulfatase C, ASC, Steroid sulfatase, Steryl-sulfate sulfohydrolase, STS, ARSC1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Arylsulfatase C / STS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conversion of sulfated steroid precursors to estrogens during pregnancy.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI).
Analysis of the STS gene in 40 patients with recessive X-linked ichthyosis: a high frequency of partial deletions in a Spanish population. Ca帽ueto J, et al. J Eur Acad Dermatol Venereol, 2010 Mar 4. PMID 20236202.
Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. Li J, et al. Breast Cancer Res, 2010. PMID 20214802.
Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Chanplakorn N, et al. Breast Cancer Res Treat, 2010 Apr. PMID 20151319.
Evidence for genetic modifiers other than filaggrin mutations in X-linked ichthyosis. Gruber R, et al. J Dermatol Sci, 2010 Apr. PMID 20149601.
Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Chakrabarti B, et al. Autism Res, 2009 Jun. PMID 19598235.
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