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Goat Anti-CD274 / PD-L1 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-CD274 / PD-L1 Antibody AF1215a
    AF1215a (4 µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
  • WB - Goat Anti-CD274 / PD-L1 Antibody AF1215a
    Antibody (4µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZQ7
Other Accession NP_054862, 29126
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5mg/ml
Isotype IgG
Calculated MW 33275 Da
Additional Information
Gene ID 29126
Other Names Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CD274 / PD-L1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD274
Synonyms B7H1, PDCD1L1, PDCD1LG1, PDL1
Function Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Research Areas
Citations (0)

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An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis. Alvarez IB, et al. J Infect Dis, 2010 Aug 15. PMID 20617899.
The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis. Raptopoulou AP, et al. Arthritis Rheum, 2010 Jul. PMID 20506224.
[Expression of B7-H1 on peripheral myeloid dendritic cells in patients with HIV infection and its correlation with diseases progression] Wang XC, et al. Zhonghua Yi Xue Za Zhi, 2010 Mar 9. PMID 20450779.
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. Pe帽a-Cruz V, et al. J Invest Dermatol, 2010 Sep. PMID 20445553.

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$ 325.00
Cat# AF1215a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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