|Application ||WB, IHC, E|
|Other Accession||NP_001257, 1066|
|Calculated MW||62521 Da|
|Other Names||Liver carboxylesterase 1, Acyl-coenzyme A:cholesterol acyltransferase, ACAT, Brain carboxylesterase hBr1, Carboxylesterase 1, CE-1, hCE-1, 22.214.171.124, Cocaine carboxylesterase, Egasyn, HMSE, Methylumbelliferyl-acetate deacetylase 1, 126.96.36.199, Monocyte/macrophage serine esterase, Retinyl ester hydrolase, REH, Serine esterase 1, Triacylglycerol hydrolase, TGH, CES1, CES2, SES1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CES1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Expressed predominantly in liver with lower levels in heart and lung.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication. Blais DR, et al. J Biol Chem, 2010 Aug 13. PMID 20530478.
Evaluation of Candidate Genes for Cholinesterase Activity in Farmworkers Exposed to Organophosphorous Pesticides - Association of SNPs in BCHE. Howard TD, et al. Environ Health Perspect, 2010 Jun 8. PMID 20529763.
Mammalian carboxylesterase 3: comparative genomics and proteomics. Holmes RS, et al. Genetica, 2010 Jul. PMID 20422440.
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity. Yamada S, et al. Pharmacogenomics J, 2010 Mar 2. PMID 20195289.
In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations. Vistoli G, et al. Bioorg Med Chem, 2010 Jan 1. PMID 19932971.
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