|Application ||WB, E|
|Other Accession||NP_000735, 1137, 11438 (mouse), 25590 (rat)|
|Predicted||Mouse, Dog, Cow|
|Calculated MW||69957 Da|
|Other Names||Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CHRNA4 (aa29-43) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
Resequencing of Nicotinic Acetylcholine Receptor Genes and Association of Common and Rare Variants with the Fagerstr枚m Test for Nicotine Dependence. Wessel J, et al. Neuropsychopharmacology, 2010 Aug 25. PMID 20736995.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Saccone NL, et al. Genes Brain Behav, 2010 Jun 22. PMID 20584212.
Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease. Hudson G, et al. Neurosci Lett, 2010 Jul 26. PMID 20493238.
Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline. Reinvang I, et al. J Int Neuropsychol Soc, 2010 May. PMID 20331911.
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