|Application ||WB, E|
|Other Accession||NP_000954, 5743|
|Predicted||Pig, Dog, Cow|
|Calculated MW||68996 Da|
|Other Names||Prostaglandin G/H synthase 2, 188.8.131.52, Cyclooxygenase-2, COX-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, PTGS2, COX2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-COX2 / PTGS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.|
|Cellular Location||Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Association Study of Interferon-gamma, Cytosolic Phospholipase A2, and Cyclooxygenase-2 Gene Polymorphisms in Alzheimer Disease. Feh茅r A, et al. Am J Geriatr Psychiatry, 2010 Jun 30. PMID 20808133.
The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis. Cao H, et al. Tohoku J Exp Med, 2010. PMID 20808059.
Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. Andersen V, et al. Inflamm Bowel Dis, 2010 Aug 27. PMID 20803508.
The cyclooxygenase-2-765C promoter polymorphism protects against the development of chronic obstructive pulmonary disease. Wu L, et al. Respir Med, 2010 Aug 17. PMID 20724130.
Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. Czerska K, et al. J Appl Genet, 2010. PMID 20720307.
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