|Application ||WB, E|
|Other Accession||NP_000090, 1471|
|Calculated MW||15799 Da|
|Other Names||Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin, CST3|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CST3 / cystatin C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.|
|Tissue Location||Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.|
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Provided below are standard protocols that you may find useful for product applications.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ, et al. Hum Mol Genet, 2010 Aug 15. PMID 20534741.
Early-pregnancy multiple serum markers and second-trimester uterine artery Doppler in predicting preeclampsia. Thilaganathan B, et al. Obstet Gynecol, 2010 Jun. PMID 20502295.
Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes. Sloan CD, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468060.
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. Laumet G, et al. J Alzheimers Dis, 2010. PMID 20413850.
Cystatin C-based formula is superior to MDRD, Cockcroft-Gault and Nankivell formulae in estimating the glomerular filtration rate in renal allografts. Qutb A, et al. Exp Clin Transplant, 2009 Dec. PMID 20353367.
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