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Goat Anti-DAZL Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-DAZL Antibody AF1303a
    AF1303a staining of paraffin embedded Mouse Testis.
  • WB - Goat Anti-DAZL Antibody AF1303a
    AF1303a (0.1 µg/ml) staining of human ovary lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92904
Other Accession NP_001342, 1618
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 33178 Da
Additional Information
Gene ID 1618
Other Names Deleted in azoospermia-like, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1, SPGY-like-autosomal, DAZL, DAZH, DAZL1, DAZLA, SPGYLA
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DAZL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Tissue Location Testis specific.
Research Areas
Citations (0)

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The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.


The dazzle in germ cell differentiation. Kerr CL, et al. J Mol Cell Biol, 2010 Feb. PMID 20008336.
A386G polymorphism of the DAZL gene is not associated with idiopathic male infertility in North India. Singh K, et al. J Hum Reprod Sci, 2009 Jul. PMID 19881148.
Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Kee K, et al. Nature, 2009 Nov 12. PMID 19865085.
Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population. Chen P, et al. J Androl, 2010 Mar-Apr. PMID 19342699.
A method for isolating pluripotent/multipotent stem cells from blood by using the pluripotent and germ-line DAZL gene as a marker. Seligman J, et al. Stem Cells Dev, 2009 Nov. PMID 19327014.

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$ 325.00
Cat# AF1303a
(40 western blots)
Availability: 7-10 days
Bulk Size
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