|Application ||WB, E|
|Other Accession||NP_005609, 28514, 13388 (mouse), 84010 (rat)|
|Calculated MW||78056 Da|
|Other Names||Delta-like protein 1, Drosophila Delta homolog 1, Delta1, H-Delta-1, DLL1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DLL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. Siar CH, et al. Eur J Med Res, 2010 Apr 8. PMID 20554499.
Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Sprinzak D, et al. Nature, 2010 May 6. PMID 20418862.
Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line. Qian CF, et al. Int J Mol Med, 2009 Oct. PMID 19724883.
Genetic variation in healthy oldest-old. Halaschek-Wiener J, et al. PLoS One, 2009 Aug 14. PMID 19680556.
Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. Ma D, et al. Ann Hematol, 2010 Feb. PMID 19603167.
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