|Application ||WB, E|
|Other Accession||NP_996770, 1826, 13508 (mouse), 171119 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||222260 Da|
|Other Names||Down syndrome cell adhesion molecule, CHD2, DSCAM|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DSCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.|
|Cellular Location||Isoform Long: Cell membrane; Single-pass type I membrane protein. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.|
|Tissue Location||Primarily expressed in brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Fuerst PG, et al. Neuron, 2009 Nov 25. PMID 19945391.
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.
Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. Yu HH, et al. J Neurosci, 2009 Feb 11. PMID 19211897.
DSCAM functions as a netrin receptor in commissural axon pathfinding. Liu G, et al. Proc Natl Acad Sci U S A, 2009 Feb 24. PMID 19196994.
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