Goat Anti-DSCAM Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O60469 |
Other Accession | NP_996770, 1826, 13508 (mouse), 171119 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 222260 Da |
Gene ID | 1826 |
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Other Names | Down syndrome cell adhesion molecule, CHD2, DSCAM |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-DSCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DSCAM |
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Function | Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1- mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). |
Cellular Location | [Isoform Short]: Secreted. |
Tissue Location | Primarily expressed in brain. |
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References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Fuerst PG, et al. Neuron, 2009 Nov 25. PMID 19945391.
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.
Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. Yu HH, et al. J Neurosci, 2009 Feb 11. PMID 19211897.
DSCAM functions as a netrin receptor in commissural axon pathfinding. Liu G, et al. Proc Natl Acad Sci U S A, 2009 Feb 24. PMID 19196994.
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