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Goat Anti-DUSP16 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9BY84 |
| Other Accession | NP_085143, 80824, 70686 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 73102 Da |
| Gene ID | 80824 |
|---|---|
| Other Names | Dual specificity protein phosphatase 16, 3.1.3.16, 3.1.3.48, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-DUSP16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUSP16 |
|---|---|
| Synonyms | KIAA1700, MKP7 |
| Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
References
DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. Lee S, et al. Br J Cancer, 2010 Jul 13. PMID 20551953.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Masuda K, et al. Biochem Biophys Res Commun, 2010 Mar 5. PMID 20122898.
SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Pi X, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19307591.
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Patterson KI, et al. Biochem J, 2009 Mar 15. PMID 19228121.
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