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Goat Anti-DUSP16 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-DUSP16 Antibody AF1345a
    AF1345a (2.5 µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BY84
Other Accession NP_085143, 80824, 70686 (mouse)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 73102 Da
Additional Information
Gene ID 80824
Other Names Dual specificity protein phosphatase 16,,, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DUSP16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP16
Synonyms KIAA1700, MKP7
Function Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Cellular Location Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles
Research Areas
Citations (0)

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This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.


DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. Lee S, et al. Br J Cancer, 2010 Jul 13. PMID 20551953.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Masuda K, et al. Biochem Biophys Res Commun, 2010 Mar 5. PMID 20122898.
SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Pi X, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19307591.
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Patterson KI, et al. Biochem J, 2009 Mar 15. PMID 19228121.

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$ 325.00
Cat# AF1345a
(40 western blots)
Availability: 7-10 days
Bulk Size
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