|Application ||IHC, E|
|Other Accession||NP_085143, 80824, 70686 (mouse)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||73102 Da|
|Other Names||Dual specificity protein phosphatase 16, 184.108.40.206, 220.127.116.11, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DUSP16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. Lee S, et al. Br J Cancer, 2010 Jul 13. PMID 20551953.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Masuda K, et al. Biochem Biophys Res Commun, 2010 Mar 5. PMID 20122898.
SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Pi X, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19307591.
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Patterson KI, et al. Biochem J, 2009 Mar 15. PMID 19228121.
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