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Goat Anti-DYX1C1 (Isoform a) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-DYX1C1 (Isoform a) Antibody AF1349a
    AF1349a staining (0.1 µg/ml) of COS1 cell lysates: untransfected (left lane) and transfected with full length recombinant Human DYX1C1 (right lane). Data kindly provided by Wang and LoTurco, University of Connecticut, USA.
  • IHC - Goat Anti-DYX1C1 (Isoform a) Antibody AF1349a
    AF1349a (5 µg/ml) staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WXU2
Other Accession NP_570722, 161582, 67685 (mouse)
Reactivity Human
Predicted Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 48527 Da
Additional Information
Gene ID 161582
Other Names Dyslexia susceptibility 1 candidate gene 1 protein, DYX1C1, EKN1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DYX1C1 (Isoform a) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DYX1C1
Synonyms EKN1
Function Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells
Research Areas
Citations (0)

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This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternate splicing results in multiple transcript variants.


Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation. Bates TC, et al. Mol Psychiatry, 2009 Nov 10. PMID 19901951.
Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Massinen S, et al. Hum Mol Genet, 2009 Aug 1. PMID 19423554.
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer. Chen Y, et al. J Cancer Res Clin Oncol, 2009 Sep. PMID 19277710.
Further evidence for DYX1C1 as a susceptibility factor for dyslexia. Dahdouh F, et al. Psychiatr Genet, 2009 Apr. PMID 19240663.
Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. Wigg KG, et al. Genes Brain Behav, 2008 Nov. PMID 19076634.

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$ 325.00
Cat# AF1349a
(40 western blots)
Availability: 7-10 days
Bulk Size
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