|Application ||WB, E|
|Other Accession||NP_004206, 9166, 55960 (mouse), 299864 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||24377 Da|
|Other Names||Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein, EBAG9, RCAS1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-EBAG9 / RCAS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases.|
|Cellular Location||Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain|
|Tissue Location||Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.
Analysis of the expression of human tumor antigens in ovarian cancer tissues. Ali-Fehmi R, et al. Cancer Biomark, 2010. PMID 20164540.
Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding. Sonoda K, et al. Exp Cell Res, 2010 Jul 1. PMID 20079734.
[Evaluation of RCAS1 as serum tumor marker for pancreatic cancer] Yang YC, et al. Zhonghua Wai Ke Za Zhi, 2009 Jul 1. PMID 19957811.
Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. Adamek D, et al. Folia Neuropathol, 2009. PMID 19813143.
Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients. Giaginis C, et al. Int J Biol Markers, 2009 Apr-Jun. PMID 19634109.
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