|Application ||WB, E|
|Other Accession||NP_001418, 2020|
|Predicted||Human, Mouse, Dog|
|Calculated MW||34211 Da|
|Other Names||Homeobox protein engrailed-2, Homeobox protein en-2, Hu-En-2, EN2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Engrailed-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Intronic single nucleotide polymorphisms of engrailed homeobox 2 modulate the disease vulnerability of autism in a han chinese population. Yang P, et al. Neuropsychobiology, 2010. PMID 20523082.
Family-based studies indicate association of Engrailed 2 gene with autism in an Indian population. Sen B, et al. Genes Brain Behav, 2010 Mar 1. PMID 20050924.
Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2. Benayed R, et al. Biol Psychiatry, 2009 Nov 15. PMID 19615670.
Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease. Rissling I, et al. Neurodegener Dis, 2009. PMID 19270442.
Engrailed-2 regulates genes related to vesicle formation and transport in cerebellar Purkinje cells. Holst MI, et al. Mol Cell Neurosci, 2008 Aug. PMID 18562208.
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